Human Phenotype Ontology

HPO — standardized terms for phenotypic abnormalities in human disease (Monarch Initiative). Returns id, name, and definition.

How to use

Search by term/synonym or HPO id (e.g. "HP:0001250"). Excludes obsolete terms by default.

Parameters

Name	Type		Description
query	string	required	Phenotype term/synonym or HPO id.
limit	number	optional	Max results (default 20).
includeObsolete	boolean	optional	Default false.

Example input

{
  "query": "seizure",
  "limit": 1
}

Example output

{
  "total": 318,
  "rows": [
    {
      "id": "HP:0001250",
      "name": "Seizure",
      "definition": "A seizure is an intermittent abnormality of nervous system physiology…"
    }
  ]
}

Call it (MCP tools/call)

{
  "method": "tools/call",
  "params": {
    "name": "lookup_hpo",
    "arguments": {
      "query": "seizure",
      "limit": 1
    }
  }
}

Endpoint: POST https://clinical-mcp.mcharge.in/mcp (Streamable HTTP).